56874 Kommentare

• Kommentar-Link Mittwoch, 02 April 2025 12:00 gepostet von PeterZep

  Exposure to phthalates during pregnancy can affect a newborn’s brain development, study finds
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  Phthalates — the synthetic chemicals used in everyday products for food packaging, personal care, toys and more — have been linked to abnormal neurological development in infants.
  
  Now, scientists may have discovered a biological pathway for how this phenomenon could occur. Researchers found that in utero exposure to phthalates is linked with altered metabolism of neurotransmitters and amino acids involved in brain maturation, according to a study published Wednesday in the journal Nature Communications.
  
  The report is the first to use untargeted metabolomics — the study of all small molecules or metabolites in a biological system — to connect a mother’s phthalate exposure to a newborn’s metabolites, and those metabolites to neurological development, said senior study author Dr. Donghai Liang via email.
  “This represents an important step forward in understanding how prenatal chemical exposures shape infant development at the molecular level,” added Liang, an associate professor of environmental health at Emory University’s Rollins School of Public Health in Atlanta.
  
  First introduced in the 1920s, phthalates are used to make plastics softer and more flexible, primarily in polyvinyl chloride (PVC) products such as vinyl flooring, medical devices, children’s toys, food packaging or shower curtains. The chemicals also help lubricate substances and carry fragrances in various personal care products including deodorant; nail polish; perfumes; hair gels, sprays or shampoos; soaps; and body lotions.
  
  Phthalates are also endocrine disruptors that have been linked to preterm birth, infant genital abnormalities, childhood obesity, asthma, cancer, cardiovascular issues, and low sperm count and testosterone in men.
  
  “We conducted this study because phthalates are everywhere in our daily lives,” Liang said, hence their nickname “everywhere chemicals.”
  
  Harming infant health
  The findings are based on mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort between 2016 and 2018. In urine samples collected from 216 mothers between eight weeks and 14 weeks of gestation at visit one and 145 participants between 24 and 30 weeks’ gestation at visit two, the authors measured eight phthalate metabolites. Participants were around age 24 on average, and their levels of some phthalate metabolites were higher than the average determined by the National Health and Nutrition Examination Survey.
  
  Within a day or two of birth, the authors collected the babies’ blood via a heel stick.
  
  The team found prenatal phthalate levels were associated with lower levels of tyrosine, an amino acid and precursor to the thyroid hormone thyroxine. Thyroxine was also abnormally low in those with in utero phthalate exposure, and low thyroxine has been previously associated with greater vulnerability to illness and neurodevelopmental issues in newborns, the authors said. Tyrosine is also a precursor to the neurotransmitters dopamine, norepinephrine and epinephrine, all of which partly contribute to the body’s fight-or-flight response. Low levels of these neurotransmitters can lead to various problems, including anxiety, depression and trouble focusing.
  
  Prenatal phthalate exposure was also linked with lower levels of the essential amino acid tryptophan, which converts into 5-hydroxytryptophan (or 5-HTP), which then turns into serotonin. Both 5-HTP and serotonin were also low. Serotonin has several critical roles in the body, including mood regulation, sleep, learning, memory, digestion and the body’s response to stress. Previous research has linked low serotonin with mood disorders such as depression and anxiety, sleep problems, and digestive issues.
• Kommentar-Link Mittwoch, 02 April 2025 04:47 gepostet von WilliamUnele

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• Kommentar-Link Dienstag, 01 April 2025 17:02 gepostet von Danielcew

  “Every morning I come downstairs and he’s already done the dishwasher, he’s already packed his lunch, and he’s ready to go,” Ruthe’s father, Ben, tells CNN Sports.
  
  “He’s just a disciplined kid. He goes to bed early, he looks after himself, he eats well, he looks after his sister. He’s just a good kid around the house in all ways, really. We’re very lucky.”
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  Ruthe is next due to compete in the 1,500 meters at the Maurie Plant Meet in Melbourne on Saturday, and one target time to aim for will be his dad’s fastest time of 3:41.22 – three hundredths of a second faster than Ruthe’s current personal best.
  But he still has a way to go before he can call himself the most decorated runner in his family. Dad Ben and mom Jess are both former national champions who represented New Zealand on the world stage, while his maternal grandparents won European championship medals for Great Britain.
  
  His grandmother, Rosemary Stirling, arguably had the most impressive achievement: an 800m Commonwealth Games title from 1970.
  
  Despite his family pedigree, Ruthe was never under any pressure to take running seriously. His parents, in fact, didn’t allow him or his sister Daisy to train at all until they were 13, never wanting their identities to be tied solely to running.
  
  “It feels like it’s the right decision about now,” says Ben.
  
  But as he gradually starts to realize his potential, Ruthe, when pushed, admits to having big goals in the sport.
  
  “If I had to pick one thing, definitely Olympic gold,” he says. “I feel like that’s most runners’ dream and the biggest thing you can actually win. So that’ll definitely be the top of my bucket list.”
  The 2032 Olympics in Brisbane, Ruthe adds, would be a nice target. And as for the Los Angeles Games in three years’ time? “I’d actually love to try and qualify for LA 28,” he says. “I feel like that’ll be a tough goal. But if I do that, I’ll be really happy.”
  
  Already, Ruthe’s name is being mentioned in the same breath as Norway’s Jakob Ingebrigtsen, the most successful middle-distance of this generation. It was his record as the youngest-ever four-minute miler that Ruthe took last week, and the New Zealander also beat Ingebrigtsen’s 1,500m record for a 15-year-old earlier this year.
  
  Ingebrigtsen’s success, Ruthe says, has given him hope that he too can “have a good future” in the sport. But his biggest source of motivation comes not from the two-time Olympic champion, but from those closest to him – his training group led by coach Craig Kirkwood and athlete Sam Tanner.
  
  The pair were instrumental in Ruthe’s recent mile time of 3:58.35, and it was five-time national champion Tanner who paced him perfectly around four laps of the track on his way to the record.
• Kommentar-Link Dienstag, 01 April 2025 15:55 gepostet von Charlesbut

  Aged 15, New Zealander Sam Ruthe has already run a four-minute mile. He would ‘love to try and qualify’ for the 2028 Olympics
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  Sam Ruthe had the eyes of thousands on him when he stepped onto a running track in Auckland just over a week ago.
  
  Undaunted by the occasion, Ruthe went on to become the first 15-year-old to run a sub-four-minute mile, even managing a nonchalant shrug of the shoulders as he crossed the finish line.
  
  The race was almost entirely engineered for the high school student to break the fabled four-minute barrier – a feat first achieved by Roger Bannister more than 70 years ago – but the weight of running history was a burden that Ruthe seemed to bear lightly.
  
  The first three laps, he later said in a video documenting the race, “felt pretty comfortable – nothing too crazy.”
  
  Perhaps the most intimidating part of his achievement occurred when Ruthe returned to school the next day, only to be immediately called into the principal’s office.
  
  “He’s like, ‘Alright, so you’re gonna have to go up on stage and we’ll get the whole school to clap you,’” Ruthe tells CNN Sports’ Patrick Snell. “It was really scary, actually. I headed into class and everyone thought I was famous.”
  
  It’s easy to forget, given his history-making performance last week, that Ruthe is like most other 15-year-olds in New Zealand. He goes to school, spends time with his friends, and helps with chores around the house.
  
  He also just happens to be one of the most exciting middle-distance runners on the planet, one of the latest star athletes to emerge from sports-mad New Zealand.
• Kommentar-Link Dienstag, 01 April 2025 15:02 gepostet von TerrySwomo

  The voice of ‘White Lotus’ star Walton Goggins is the lullaby we didn’t know we needed
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  While his “White Lotus” character Rick has been the source of some stress this season, Walton Goggins is here to soothe us into a state of dreamy sleep to make up for it.
  
  The actor has partnered with relaxation and meditation app Calm for one of their famed Sleep Stories, lending his smoky voice to a fable titled “The Yard Sale.”
  
  Goggins announced the Sleep Story on his verified Instagram on Tuesday, writing, “A friend once said to me the first question you ask someone shouldn’t be, ‘How are you?’ but rather, ‘How did you sleep last night?’ I agree.”
  
  The post included an excerpt from the story, in which Goggins is heard languidly instructing listeners to relax their bodies and get into bed. “You could even climb into a hammock,” he added. “I wouldn’t do that because I’ve never gracefully got in or out of one.”
  
  In the caption, the actor also wrote that he “wanted to create a Sleep Story that feels dreamlike, helping people slow their minds down by wandering through a yard sale (which happens to be one of my favorite things to do), uncovering hidden treasures.”
  
  “It’s the Walton Goggins version of counting sheep. I hope you enjoy,” he added.
  
  Other celebrities who have read bedtime stories in the hopes of putting audiences to sleep include Dolly Parton and the late Jimmy Stewart, whose voice was featured in a Calm Christmas Sleep Story in 2023 thanks to generative AI technology.
  
  Goggins currently stars on “The White Lotus,” where his character is often the most stressed out and tortured of the ensemble, at one point setting a slew of snakes free.
• Kommentar-Link Dienstag, 01 April 2025 14:44 gepostet von HowardpeK

  Tyler O’Neill hits record-extending sixth straight Opening Day home run
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  For six seasons in a row, Tyler O’Neill has homered on MLB Opening Day.
  
  Making his debut for the Baltimore Orioles on Thursday, O’Neill started the season with his record-extending sixth straight home run on Opening Day during his team’s 12-2 win against the Toronto Blue Jays.
  
  No other player has homered on more than four consecutive Opening Days, with the 29-year-old outfielder’s three-run shot sending the Orioles into a 5-0 lead at the top of the third at Rogers Centre.
  Todd Hundley (1994-97), Gary Carter (1977-80) and Yogi Berra (1955-58) all hit four consecutive home runs on Opening Day, while the Major League Baseball record for the total number of Opening Day home runs is held jointly by Adam Dunn, Ken Griffey Jr. and Frank Robinson on eight.
  
  “I’m just not trying to make too much of it,” O’Neill told reporters about his streak. “I’m just trying to go out, have a good first at-bat and see what the game gives me from there.
  
  “Obviously, I understand what’s going on, but it’s not like I’m going out there trying to do anything crazy.”
  
  O’Neill, who signed a three-year, $49.5 million contract to join Baltimore from the Boston Red Sox in the offseason, finished three-for-three with three RBIs and two walks against the Blue Jays.
  
  “It’s a little different when the lights turn on and you’ve got to show up, so it was really cool to see all the guys show up today,” he said. “We got after it out there.”
  
  While the first two games of the MLB regular season took place between the Chicago Cubs and Los Angeles Dodgers in Tokyo last week, Thursday marked the first official day of the season in the United States.
• Kommentar-Link Dienstag, 01 April 2025 11:32 gepostet von AllanTen

  A tiny rainforest country is growing into a petrostate. A US oil company could reap the biggest rewards
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  Guyana’s destiny changed in 2015. US fossil fuel giant Exxon discovered nearly 11 billion barrels of oil in the deep water off the coast of this tiny, rainforested country.
  
  It was one of the most spectacular oil discoveries of recent decades. By 2019, Exxon and its partners, US oil company Hess and China-headquartered CNOOC, had started producing the fossil fuel.? They now pump around 650,000 barrels of oil a day, with plans to more than double this to 1.3 million by 2027.
  
  Guyana now has the world’s highest expected oil production growth through 2035.
  
  This country — sandwiched between Brazil, Venezuela and Suriname — has been hailed as a climate champion for the lush, well-preserved forests that carpet nearly 90% of its land. It is on the path to becoming a petrostate at the same time as the impacts of the fossil fuel-driven climate crisis escalate.
  
  While the government says environmental protection and an oil industry can go hand-in-hand, and low-income countries must be allowed to exploit their own resources, critics say it’s a dangerous path in a warming world, and the benefits may ultimately skew toward Exxon — not Guyana.
  Since Exxon’s transformative discovery, Guyana’s government has tightly embraced oil as a route to prosperity. In December 2019, then-President David Granger said in a speech, “petroleum resources will be utilized to provide the good life for all … Every Guyanese will benefit.”
  
  It’s a narrative that has continued under current President Mohamed Irfaan Ali, who says new oil wealth will allow Guyana to develop better infrastructure, healthcare and climate adaptation.
• Kommentar-Link Dienstag, 01 April 2025 09:40 gepostet von Kennethbed

  Of course, he said yes to coming back to the series, which eventually required him to live in Italy for a few months for filming.
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  During production, White revealed to Gries that Greg is “very sinister.” That became rather irrefutable by the season’s climax, which saw Tanya’s demise orchestrated by her now-husband.
  
  Come Season 3, Gries had to rewrite Greg’s backstory again, this time drawing from some unlikely sources for inspiration, like HBO docuseries “The Jinx,” about late convicted killer Robert Durst, and the case involving the man who came to be known as the Tinder Swindler.
  
  Gries said he was struck by Durst’s “kind of seemingly even keel personality,” which served as a model for where Greg was headed, someone “who doesn’t really show a great deal of emotion, doesn’t seem to get too angry, just gets a little bit irritated and is dangerous.”
  
  “There’s a bridled rage underneath. And those kind of people I find – at least with respect to Gary, Greg, Gary – fascinating,” he said.
  
  And yet, while searching for an empathetic way back to portraying his character, Gries kept wondering if there was anything still redeeming about Greg.
  An important “wake up moment” came during a decisive conversation he had with White just before filming in Thailand, in which the show’s creator said of Greg, in no uncertain terms: “He’s a psychopath.”
  
  “And that was it. It was like, ‘back to the drawing board.’ And it really did help me,” Gries said.
  
  The penultimate episode of the series will air on Sunday, an evening that thanks to “Lotus” and other shows has again become a night of appointment viewing amid a general move away from binge watching. Gries said he appreciates the shift.
  
  “We’re a society that in a weird way doesn’t understand the beauty of waiting. The beauty of the space between the notes,” he shared. “If I binged (‘White Lotus’) I’d feel like I just ate too many chocolates. It just wouldn’t be the same. You need to process this.”
  
  “The White Lotus” airs Sundays at 9 p.m. EDT on HBO, with the episode available to stream on Max. HBO and Max, like CNN, are owned by the same parent company, Warner Bros. Discovery.
• Kommentar-Link Dienstag, 01 April 2025 09:32 gepostet von RobertTenry

  Look of the Week: Naomi Watts is twinning with her canine co-star
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  What’s white and black and red all over? Naomi Watts and her 145lb co-star, Bing, a Great Dane, taking a dog walk on the crimson carpet for the New York premiere of “The Friend.”
  
  Directed by Scott Mcgehee and adapted from Sigrid Nunez’s 2018 novel of the same name, the film — set to release in US theaters on March 28 and in the UK on April 25 — follows a solitary writer and teacher named Iris whose life is upended after a close friend bequeaths his giant pet dog to her following his death.
  
  In front of the cameras Monday evening, the “Mulholland Drive” actor and Bing looked like they were cut from the same cloth — both in temperament and in their matching black polka dots. Watts was dressed in a white gown with fur-tufted spots that bore a striking resemblance to Bing’s own coat, but the Cruella de Vil comparisons ended there. Instead, Watts and Bing were captured in the throes of lots of paw-shakes, puppy kisses and head scratches.
  The dress that Watts wore, titled the “Domino” and designed by Jacquemus, debuted during the Spring-Summer 2025 Paris couture shows in January. The look was both elegant and offbeat, with a high-cowl neck and open-back, asymmetrical waistline that mimicked a French tuck. It was styled with a skirt that sprouted furry black polka dots, which close up were unnervingly reminiscent of body hair. But from afar they gave the impression of soft-edged dabs of watercolor bleeding downstream.
  
  The look was styled by Jeanann Williams, who has also been working with “The White Lotus” star Leslie Bibb. Williams’ decision to coordinate Watts with Bing was a new take on method dressing — the thematic styling trend that has dominated celebrity red carpets since Greta Gerwig’s “Barbie” in 2023. Since then, the sartorial trope, which connects actors to their on-screen characters through clothes, has become somewhat tired — with some observers claiming that the 7-month-long “Wicked” press tour, in which Cynthia Erivo and Ariana Grande became prisoners to the colors green and pink, was peak saturation.
• Kommentar-Link Dienstag, 01 April 2025 08:25 gepostet von Danielzef

  ‘White Lotus’ villain Jon Gries reveals the true crimes that inspired his twisty take on Greg/Gary
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  When Season 3 of “The White Lotus” premiered last month, the shock was palpable when returning character Belinda recognized a familiar face at the resort in Thailand: Greg Hunt, the wily suitor of the late Tanya McQuoid.
  
  As the season has unfolded, Greg (played by Jon Gries) has emerged as an antagonist, particularly after Belinda dove into the investigation surrounding Tanya’s death and learned that Greg, who now goes by Gary, evaded questioning by authorities.
  
  On a show famous for reinventing itself, the same has been asked of the actor, who says that playing the ever-shifting character has been a welcome challenge and, like “White Lotus” itself, full of twists.
  
  “In the beginning, I totally played him for a guy who was, you know, on his last legs,” Gries said in a recent interview with CNN, referencing Greg’s very apparent ill health in the first season of “White Lotus,” which premiered to rave reviews in summer 2021. He added: “When you play a character, you want to find his empathetic side, and you want to understand where they came from, and what got them to where they are.”
  
  But when he was contacted by creator Mike White about appearing in Season 2, Gries realized he would have to adjust his framing of Greg, despite having previously imagined a “comprehensive history” for him on his own.
  
  “(White) said, ‘I’m writing it right now, and I’m writing you, and I just need to know here and now: If you’re in, I’ll continue writing. If not, I’ll stop,’” Gries recalled.